NutriStack
Prednisolone and Vitamin D3, a synergy.
Chronic prednisolone use increases the risk of osteoporosis and fractures. Vitamin D3 helps maintain calcium absorption and is routinely paired with calcium in glucocorticoid-induced osteoporosis prevention plans.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Prednisolone and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Chronic prednisolone use increases the risk of osteoporosis and fractures. Vitamin D3 helps maintain calcium absorption and is routinely paired with calcium in glucocorticoid-induced osteoporosis prevention plans.
Mechanism. Glucocorticoids impair calcium homeostasis and bone remodeling, partly by reducing intestinal calcium absorption and osteoblast function. Vitamin D3 supports calcium absorption and helps counter one component of steroid-driven bone loss.
Recommendation. Maintain adequate vitamin D intake while on long-term prednisolone and have 25-OH vitamin D checked if your risk is high or therapy is prolonged. Do not rely on vitamin D3 alone if your steroid dose, age, prior fracture history, or bone density indicates need for prescription osteoporosis therapy.
Sources (2)
- Humphrey MB, Russell L, Danila MI, et al. 2022 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis. Arthritis Care Res (Hoboken). 2023;75(12):2405-2419. PMID 37884467
- Homik J, Suarez-Almazor ME, Shea B, Cranney A, Wells G, Tugwell P. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000;1998(2):CD000952. PMID 10796394
Stack Score
How this pair moves the number.
Effect on the composite score
If both Prednisolone and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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