From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Pair type
Timing Sensitive
Scope
Supplement × Supplement
Last verified
June 4, 2026
Timing SensitiveInsufficient evidence
What is happening. High-dose plant sterols can modestly reduce absorption of some fat-soluble dietary compounds; clinically important vitamin D effects are not well proven.
Mechanism. Competition in intestinal lipid micelles is possible at high plant sterol intakes.
Recommendation. Take vitamin D with a meal and monitor 25-hydroxyvitamin D if deficiency is being treated.
Stack Score
How it moves the number.
Effect on the composite score
If both Beta-Sitosterol and Vitamin D3 are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Gylling H et al. Plant sterols and plant stanols review. Atherosclerosis. 2014.Needs sourceNo link