Supplement × Supplement·timing-sensitive·Insufficient evidence

Beta-Sitosterol + Vitamin D3

Timing Sensitive Insufficient evidence

High-dose plant sterols can modestly reduce absorption of some fat-soluble dietary compounds; clinically important vitamin D effects are not well proven.

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Pair type
Timing Sensitive
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
Timing SensitiveInsufficient evidence

What is happening. High-dose plant sterols can modestly reduce absorption of some fat-soluble dietary compounds; clinically important vitamin D effects are not well proven.

Mechanism. Competition in intestinal lipid micelles is possible at high plant sterol intakes.

Recommendation. Take vitamin D with a meal and monitor 25-hydroxyvitamin D if deficiency is being treated.

Stack Score

How it moves the number.

Effect on the composite score

If both Beta-Sitosterol and Vitamin D3 are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Gylling H et al. Plant sterols and plant stanols review. Atherosclerosis. 2014.Needs sourceNo link

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