From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyModerate evidence
What is happening. Vitamin D therapy can help maintain calcium balance but can also change calcium and phosphate response during cinacalcet treatment.
Mechanism. Vitamin D increases calcium absorption while cinacalcet lowers PTH-mediated calcium mobilization.
Recommendation. Use only as directed and monitor calcium, phosphorus, and PTH after changes.
Stack Score
How it moves the number.
Effect on the composite score
If both Cinacalcet and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1KDIGO. CKD-MBD Guideline Update. Kidney International Supplements. 2017.Needs sourceNo link