NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Boron and Vitamin D3: what the published research says

PubMed indexes 8 records that name Boron and Vitamin D3 together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Boron and Vitamin D3. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Boron and Vitamin D3.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effects of dietary boron supplementation on some biochemical parameters, peripheral blood lymphocytes, splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol (vitamin D3) content.

British poultry science · 2005 · PMID 15835257

Animal study

“Whole blood haematocrit and haemoglobin counts were significantly increased by boron supplementation but there were no effects on leucocyte ratios such as eosinophil, basophil, monocyte, lymphocyte and thrombocyte. (4) In general, the findings of the present study support the hypothesis that boron has an important biological role that affects the mineral metabolism of animals by influencing both biochemical and haematological mechanisms.”

Kurtoğlu et al. · From the abstract

Names both Boron and Vitamin D3 in its title.

Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1994 · PMID 8140930

Animal study

“A ninefold increase in dietary boron yielded only a two-fold increase in plasma boron concentration and no increase in femur boron concentration, which suggests that boron is under homeostatic control. The findings suggest that boron acts on at least three separate metabolic sites because it compensates for perturbations in energy substrate utilization induced by vitamin D3 deficiency, enhances major mineral content in bone, and, independently of vitamin D3, enhances some…”

Hunt et al. · From the abstract

Names both Boron and Vitamin D3 in its title.

Studies to determine whether an interaction exists among boron, calcium, and cholecalciferol on the skeletal development of broiler chickens.

Poultry science · 1992 · PMID 1317562

Research Support, U.S. Gov't, Non-P.H.S.Animal study

“The only response to boron in Experiments 3 to 6 was a boron effect and a boron by cholecalciferol interaction on bone ash in Experiment 3, in which boron reduced bone ash at .65% calcium and 110 ICU/kg cholecalciferol. From these experiments, there is no indication that an interaction among boron, cholecalciferol, and calcium exists in broiler cockerels.”

Elliot et al. · From the abstract

Names both Boron and Vitamin D3 in its title.

Boron affects energy metabolism in the streptozotocin-injected, vitamin D3-deprived rat.

Magnesium and trace elements · 1991 · PMID 1669021

Animal study

“The finding that boron did not affect growth, but did affect several indices of energy metabolism in the non-STZ animals suggests that boron functions as a regulator of energy metabolism in the rat. A decrease in plasma aspartate transaminase activity (an indicator of enhanced cell membrane integrity) in the non-STZ rats suggests that boron exerts a protective influence over normal liver metabolism.”

Hunt et al. · From the abstract

Names both Boron and Vitamin D3 in its title.

Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat.

Magnesium and trace elements · 1991 · PMID 1669022

Animal study

“Finally, boron may have indirectly affected heart mineral metabolism because dietary boron did not affect cardiac boron concentrations but did affect cardiac copper, calcium, manganese, molybdenum and phosphorus concentrations, primarily in non-STZ rats. The findings suggest that dietary boron has both protective and regulatory roles in mineral metabolism.”

Hunt et al. · From the abstract

Names both Boron and Vitamin D3 in its title.

Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick.

Biological trace element research · 1989 · PMID 2484240

Animal study

“An interaction among B, Mg, and Mo affected plasma uric acid and glucose concentrations. B may function to modify mineral metabolism in cholecalciferol deficiency, suppressing bone anabolism in concurrent Mg deficiency and bone catabolism in concurrent Mg adequacy.”

Hunt · From the abstract

Names both Boron and Vitamin D3 in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Boron, Vitamin D3, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.