NutriStack
Boron and Testosterone, a caution.
In a small trial, daily boron 10 mg raised free testosterone and modestly lowered estradiol in healthy men over one week. The clinical impact on top of prescribed testosterone is likely small but may shift the androgen-to-estrogen ratio and complicate monitoring.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Boron and Testosterone
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. In a small trial, daily boron 10 mg raised free testosterone and modestly lowered estradiol in healthy men over one week. The clinical impact on top of prescribed testosterone is likely small but may shift the androgen-to-estrogen ratio and complicate monitoring.
Mechanism. Boron appears to reduce SHBG and inhibit aromatase activity, raising free testosterone and lowering estradiol. It also influences vitamin D metabolism, which interacts with androgen pathways.
Recommendation. Routine boron supplementation is generally safe at 3-10 mg/day, but is not needed alongside prescribed testosterone. If used, keep the dose modest (3 mg/day from a multivitamin is fine) and discuss with your prescriber.
Sources (2)
- Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2011;25(1):54-8. PMID 21129941
- Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas). 2015;14(4):35-48. PMID 26770156
Stack Score
How this pair moves the number.
Effect on the composite score
If both Boron and Testosterone are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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