Supplement × Prescription·a caution·Emerging evidence
Quercetin can inhibit some CYP enzymes and transporters in vitro, which could make roflumilast tolerability less predictable.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Quercetin can inhibit some CYP enzymes and transporters in vitro, which could make roflumilast tolerability less predictable.
Mechanism. Potential modulation of CYP3A4, CYP1A2, or transporters involved in roflumilast disposition.
Recommendation. Use cautiously when starting or stopping high-dose quercetin; monitor diarrhea, nausea, weight loss, and mood symptoms.
Effect on the composite score
If both Quercetin and Roflumilast are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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