Supplement × Prescription·a caution·Emerging evidence
Berberine may affect CYP enzymes and P-glycoprotein, creating theoretical exposure changes for roflumilast.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Berberine may affect CYP enzymes and P-glycoprotein, creating theoretical exposure changes for roflumilast.
Mechanism. Potential CYP and transporter modulation.
Recommendation. Avoid adding high-dose berberine without clinician review if roflumilast adverse effects or severe COPD instability are present.
Effect on the composite score
If both Berberine and Roflumilast are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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