From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Caffeinated green tea extract may compound roflumilast-associated insomnia, anxiety, tremor, or appetite suppression.
Mechanism. Additive stimulant and appetite-suppressing effects.
Recommendation. Avoid high-caffeine extracts if insomnia, anxiety, palpitations, or weight loss occurs.
Stack Score
How it moves the number.
Effect on the composite score
If both Green Tea Extract and Roflumilast are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Roflumilast Tablets US Prescribing Information. 2026.Needs sourceNo link