Supplement × Prescription·a caution·Emerging evidence

Quercetin + Silodosin

Caution Emerging evidence

High-dose quercetin may inhibit CYP3A4 or P-glycoprotein and could increase silodosin exposure.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence

What is happening. High-dose quercetin may inhibit CYP3A4 or P-glycoprotein and could increase silodosin exposure.

Mechanism. Potential CYP3A4 and transporter inhibition.

Recommendation. Monitor for dizziness, low blood pressure, or ejaculatory adverse effects when starting or stopping high-dose quercetin.

Stack Score

How it moves the number.

Effect on the composite score

If both Quercetin and Silodosin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1U.S. National Library of Medicine. Silodosin Capsules US Prescribing Information. 2026.Needs sourceNo link

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