Supplement × Prescription·a conflict·Emerging evidence
St. John's Wort can induce CYP3A4 and P-glycoprotein and may reduce silodosin exposure.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can induce CYP3A4 and P-glycoprotein and may reduce silodosin exposure.
Mechanism. Enzyme and transporter induction can lower substrate concentrations.
Recommendation. Avoid unsupervised use if urinary symptom control depends on silodosin.
Effect on the composite score
If both Silodosin and St. John's Wort are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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