From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. L-citrulline can increase nitric oxide availability and may add to silodosin-related dizziness or orthostatic hypotension.
Mechanism. Additive vasodilatory and blood pressure-lowering effects.
Recommendation. Use cautiously when starting or titrating silodosin; monitor standing dizziness and falls.
Stack Score
How it moves the number.
Effect on the composite score
If both L-Citrulline and Silodosin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Silodosin Capsules US Prescribing Information. 2026.Needs sourceNo link