From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
ConflictEmerging evidence
What is happening. Rhodiola may have stimulant or monoaminergic effects that are poorly predictable during nonselective MAO inhibition.
Mechanism. Potential additive monoaminergic stimulation may increase agitation, insomnia, blood pressure, or serotonin toxicity risk.
Recommendation. Avoid rhodiola while taking tranylcypromine.
Stack Score
How it moves the number.
Effect on the composite score
If both Rhodiola Rosea and Tranylcypromine are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1StatPearls Publishing. Tranylcypromine. NCBI Bookshelf. 2025.Needs sourceNo link