Supplement × Prescription·contraindicated·Strong evidence
St. John's Wort has serotonergic effects and is unsafe with irreversible MAOIs.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort has serotonergic effects and is unsafe with irreversible MAOIs.
Mechanism. Serotonergic herb activity during MAO-A and MAO-B inhibition increases serotonin syndrome risk.
Recommendation. Do not use St. John's Wort with tranylcypromine.
Effect on the composite score
If both St. John's Wort and Tranylcypromine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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