Supplement × Prescription·a conflict·Emerging evidence

Phenelzine + Rhodiola Rosea

Conflict Emerging evidence

Rhodiola may have stimulant and monoaminergic effects, which are risky during nonselective MAO inhibition.

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Pair type
Conflict
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
ConflictEmerging evidence

What is happening. Rhodiola may have stimulant and monoaminergic effects, which are risky during nonselective MAO inhibition.

Mechanism. Possible additive monoaminergic stimulation can raise risks of hypertension, agitation, insomnia, or serotonin toxicity.

Recommendation. Avoid rhodiola while taking phenelzine.

Stack Score

How it moves the number.

Effect on the composite score

If both Phenelzine and Rhodiola Rosea are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Gillman PK. The prescriber's guide to the MAOI diet - thinking through tyramine troubles. J Neural Transm. 2018.Needs sourceNo link

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