Supplement × Prescription·a caution·Emerging evidence
High-dose vitamin C can increase urinary oxalate in some patients. Zonisamide increases kidney stone risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. High-dose vitamin C can increase urinary oxalate in some patients. Zonisamide increases kidney stone risk.
Mechanism. Potential additive kidney stone risk through oxalate load plus carbonic anhydrase inhibitor effects on urinary chemistry.
Recommendation. Avoid high-dose vitamin C in patients with kidney stone history or zonisamide-related stone risk unless approved by the clinician.
Effect on the composite score
If both Vitamin C and Zonisamide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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