From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Potassium citrate or alkali therapy may be used medically for acidosis or stones, but unsupervised potassium can be unsafe.
Mechanism. Alkali therapy may correct acidosis, but potassium accumulation can occur in renal impairment or with potassium-retaining drugs.
Recommendation. Use potassium-containing alkali only under clinician guidance with electrolyte and kidney monitoring.
Stack Score
How it moves the number.
Effect on the composite score
If both Potassium and Zonisamide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Azurity Pharmaceuticals Inc. ZONISADE US Prescribing Information. 2025.Needs sourceNo link