NutriStack
CautionEmerging evidence
What is happening. Melatonin can add to zonisamide-related somnolence, dizziness, or cognitive slowing.
Mechanism. Additive CNS depression.
Recommendation. Use cautiously and monitor next-day alertness.
Supplement × Prescription·a caution·Emerging evidence
Melatonin + Zonisamide
Caution
Emerging evidence
Melatonin can add to zonisamide-related somnolence, dizziness, or cognitive slowing.
From the database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Substances
Melatonin and Zonisamide
Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
Stack Score
How it moves the number.
Effect on the composite score
If both Melatonin and Zonisamide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Sources
Sources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Azurity Pharmaceuticals Inc. ZONISADE US Prescribing Information. 2025.Needs sourceNo link
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