Medication·Interactions & depletion·Reviewed June 9, 2026
Aluminum/Magnesium Hydroxide interactions.
Aluminum/Magnesium Hydroxide has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus, Iron, Vitamin B12, and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Aluminum/Magnesium Hydroxide at a glance.
A quick, data-grounded summary. The full tables are below.
Aluminum/Magnesium Hydroxide has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Phosphorus, Iron, Vitamin B12, and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with aluminum/magnesium hydroxide.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ciprofloxacin | Timing Sensitive | Aluminum and magnesium in antacids form insoluble chelate complexes with ciprofloxacin in the gut, dramatically reducing antibiotic absorption.... details → |
| Doxycycline | Timing Sensitive | Aluminum and magnesium in antacids chelate doxycycline in the gut, dramatically reducing its absorption. Bioavailability reductions of 50 percent or... details → |
| Levofloxacin | Timing Sensitive | Aluminum and magnesium in antacids form insoluble chelate complexes with levofloxacin in the gut, reducing antibiotic absorption by 50 percent or... details → |
What aluminum/magnesium hydroxide can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Phosphorus | Significant | Aluminum-containing antacids bind phosphate in the gut and can lower phosphorus status during repeated use. | – | Serum phosphorus |
| Iron | Mild | Antacids reduce iron absorption by raising gastric pH and reducing non-heme iron solubility. | Iron Bisglycinate | Ferritin + transferrin saturation |
| Vitamin B12 | Mild | Reduced gastric acidity can impair release of food-bound B12 and lower long-term absorption. | Methylcobalamin | Serum B12 + methylmalonic acid |
| Folate | Mild | Antacid-related pH changes can modestly reduce folate absorption during chronic use. | Methylfolate | Serum folate or RBC folate |
The full aluminum/magnesium hydroxide profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common aluminum/magnesium hydroxide questions.
Quick answers drawn from the tables above.
What interacts with Aluminum/Magnesium Hydroxide?
In the NutriStack database, Aluminum/Magnesium Hydroxide has 3 documented interactions. The most notable include Ciprofloxacin, Doxycycline, and Levofloxacin. Check any specific combination before taking it and confirm with your prescriber.
Does Aluminum/Magnesium Hydroxide deplete any nutrients?
Aluminum/Magnesium Hydroxide is associated with lowering Phosphorus, Iron, Vitamin B12, and Folate with prolonged use. Useful biomarkers to monitor include Serum phosphorus, Ferritin + transferrin saturation, and Serum B12 + methylmalonic acid. Ask your prescriber before adding any replacement supplement.
Is it safe to take Ciprofloxacin with Aluminum/Magnesium Hydroxide?
NutriStack classifies the Ciprofloxacin and Aluminum/Magnesium Hydroxide pairing as timing sensitive: Aluminum and magnesium in antacids form insoluble chelate complexes with ciprofloxacin in the gut, dramatically reducing antibiotic absorption. Studies have shown... Take ciprofloxacin at least 2 hours before or 6 hours after any aluminum or magnesium hydroxide antacid. Do not co-administer in the same dose. Always confirm with your prescriber.
Check your whole stack
See how aluminum/magnesium hydroxide fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.