Medication·Interactions & depletion·Reviewed June 9, 2026
Amitriptyline interactions.
Amitriptyline has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Amitriptyline at a glance.
A quick, data-grounded summary. The full tables are below.
Amitriptyline has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with amitriptyline.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Alcohol can markedly worsen amitriptyline-related impairment. Human studies found ethanol increased free amitriptyline exposure during absorption... details → |
| Sertraline | Caution | Combining an SSRI with a tricyclic antidepressant increases the risk of serotonin syndrome and may elevate TCA blood levels due to CYP2D6... details → |
| St. John's Wort | Caution | St. John's Wort can substantially lower amitriptyline and nortriptyline exposure, which may cause loss of antidepressant, migraine, sleep, or... details → |
What amitriptyline can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Sodium | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | – | Serum sodium |
The full amitriptyline profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amitriptyline questions.
Quick answers drawn from the tables above.
What interacts with Amitriptyline?
In the NutriStack database, Amitriptyline has 3 documented interactions. The most notable include Alcohol, Sertraline, and St. John's Wort. Check any specific combination before taking it and confirm with your prescriber.
Does Amitriptyline deplete any nutrients?
Amitriptyline is associated with lowering Sodium with prolonged use. Useful biomarkers to monitor include Serum sodium. Ask your prescriber before adding any replacement supplement.
Is it safe to take Alcohol with Amitriptyline?
NutriStack classifies the Alcohol and Amitriptyline pairing as caution: Alcohol can markedly worsen amitriptyline-related impairment. Human studies found ethanol increased free amitriptyline exposure during absorption and greatly worsened... Avoid alcohol while taking amitriptyline, especially near bedtime doses or before driving. If you drink despite this, keep intake very low and do... Always confirm with your prescriber.
Check your whole stack
See how amitriptyline fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.