Medication·Interactions & depletion·Reviewed June 9, 2026
Amoxicillin interactions.
Amoxicillin has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Amoxicillin at a glance.
A quick, data-grounded summary. The full tables are below.
Amoxicillin has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with amoxicillin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Lactobacillus Rhamnosus | Synergy | Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea in patients on amoxicillin, with the strongest pediatric evidence among probiotic... details → |
| Probiotics | Synergy | Probiotic supplementation during amoxicillin therapy reduces antibiotic-associated diarrhea and helps preserve gut microbiome diversity. Although... details → |
| Saccharomyces Boulardii | Synergy | Saccharomyces boulardii reduces antibiotic-associated diarrhea during amoxicillin therapy and is unaffected by the antibiotic because it is a yeast.... details → |
What amoxicillin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum antibiotic exposure can suppress gut bacteria that synthesize menaquinones, lowering vitamin K availability in susceptible patients. | – | PT/INR |
The full amoxicillin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amoxicillin questions.
Quick answers drawn from the tables above.
What interacts with Amoxicillin?
In the NutriStack database, Amoxicillin has 3 documented interactions. The most notable include Lactobacillus Rhamnosus, Probiotics, and Saccharomyces Boulardii. Check any specific combination before taking it and confirm with your prescriber.
Does Amoxicillin deplete any nutrients?
Amoxicillin is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include PT/INR. Ask your prescriber before adding any replacement supplement.
Is it safe to take Lactobacillus Rhamnosus with Amoxicillin?
NutriStack classifies the Lactobacillus Rhamnosus and Amoxicillin pairing as synergy: Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea in patients on amoxicillin, with the strongest pediatric evidence among probiotic strains. Separation... Take Lactobacillus rhamnosus throughout your amoxicillin course, separated by at least 2 hours from each antibiotic dose. Continue for at least 1... Always confirm with your prescriber.
Check your whole stack
See how amoxicillin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.