Medication·Interactions & depletion·Reviewed June 9, 2026
Amoxicillin-Clavulanate interactions.
Amoxicillin-Clavulanate has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Amoxicillin-Clavulanate at a glance.
A quick, data-grounded summary. The full tables are below.
Amoxicillin-Clavulanate has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with amoxicillin-clavulanate.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Lactobacillus Rhamnosus | Synergy | Lactobacillus rhamnosus GG reduces the elevated antibiotic-associated diarrhea risk associated with amoxicillin-clavulanate, including in pediatric... details → |
| Probiotics | Synergy | Amoxicillin-clavulanate has notably higher rates of antibiotic-associated diarrhea than plain amoxicillin, largely due to the clavulanate component.... details → |
| Saccharomyces Boulardii | Synergy | Saccharomyces boulardii reduces the elevated antibiotic-associated diarrhea risk of amoxicillin-clavulanate. Because it is a yeast, it is unaffected... details → |
What amoxicillin-clavulanate can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum antibiotic exposure can suppress gut bacteria that synthesize menaquinones, lowering vitamin K availability in susceptible patients. | – | PT/INR |
The full amoxicillin-clavulanate profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common amoxicillin-clavulanate questions.
Quick answers drawn from the tables above.
What interacts with Amoxicillin-Clavulanate?
In the NutriStack database, Amoxicillin-Clavulanate has 3 documented interactions. The most notable include Lactobacillus Rhamnosus, Probiotics, and Saccharomyces Boulardii. Check any specific combination before taking it and confirm with your prescriber.
Does Amoxicillin-Clavulanate deplete any nutrients?
Amoxicillin-Clavulanate is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include PT/INR. Ask your prescriber before adding any replacement supplement.
Is it safe to take Lactobacillus Rhamnosus with Amoxicillin-Clavulanate?
NutriStack classifies the Lactobacillus Rhamnosus and Amoxicillin-Clavulanate pairing as synergy: Lactobacillus rhamnosus GG reduces the elevated antibiotic-associated diarrhea risk associated with amoxicillin-clavulanate, including in pediatric patients. Separation... Take Lactobacillus rhamnosus throughout your amoxicillin-clavulanate course, separated by at least 2 hours from each antibiotic dose. Continue for... Always confirm with your prescriber.
Check your whole stack
See how amoxicillin-clavulanate fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.