Medication·Interactions & depletion·Reviewed June 9, 2026
Ampicillin interactions.
Ampicillin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Ampicillin at a glance.
A quick, data-grounded summary. The full tables are below.
Ampicillin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with ampicillin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin K1 | Caution | Prolonged Ampicillin therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor... |
| Vitamin K2 | Caution | Broad-spectrum antibiotics such as ampicillin can suppress vitamin K-producing gut bacteria, occasionally lowering vitamin K status. This is most... |
| Calcium | Timing Sensitive | Calcium is a divalent cation that can theoretically chelate beta-lactam antibiotics, and large meals or dairy can reduce ampicillin absorption.... |
| Probiotics | Timing Sensitive | Ampicillin can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower... |
| Zinc | Timing Sensitive | Although chelation interactions with penicillins are far less pronounced than with tetracyclines or fluoroquinolones, divalent cations such as zinc... |
What ampicillin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum aminopenicillins suppress the colonic bacteria (notably Bacteroides and other anaerobes) that synthesize menaquinones (vitamin K2).... | Vitamin K1 (phylloquinone) | Prothrombin time / INR (most useful in patients on warfarin or with poor nutritional status) |
The full ampicillin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ampicillin questions.
Quick answers drawn from the tables above.
What interacts with Ampicillin?
In the NutriStack database, Ampicillin has 5 documented interactions. The most notable include Vitamin K1, Vitamin K2, Calcium, Probiotics, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Does Ampicillin deplete any nutrients?
Ampicillin is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include Prothrombin time / INR (most useful in patients on warfarin or with poor nutritional status). Ask your prescriber before adding any replacement supplement.
Is it safe to take Vitamin K1 with Ampicillin?
NutriStack classifies the Vitamin K1 and Ampicillin pairing as caution: Prolonged Ampicillin therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor intake,... Do not self-treat bleeding or INR changes. Monitor for bruising or bleeding and coordinate vitamin K or anticoagulant changes with the prescriber. Always confirm with your prescriber.
Check your whole stack
See how ampicillin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.