Medication·Interactions & depletion·Reviewed June 9, 2026
Atorvastatin interactions.
Atorvastatin has 12 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Atorvastatin at a glance.
A quick, data-grounded summary. The full tables are below.
Atorvastatin has 12 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with atorvastatin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Green Tea Extract | Conflict | Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced... details → |
| St. John's Wort | Conflict | St. John's Wort is a potent CYP3A4 inducer that significantly increases atorvastatin metabolism, reducing its plasma levels and cholesterol-lowering... details → |
| Berberine | Caution | Berberine has human evidence of inhibiting CYP3A4 activity after repeated dosing, and atorvastatin is partly cleared through CYP3A4. This could... |
| Clarithromycin | Caution | Clarithromycin inhibits CYP3A4, increasing atorvastatin levels. While less dramatic than simvastatin interaction (atorvastatin is partially CYP3A4... details → |
| Ginkgo Biloba | Caution | A human study found that high-dose Ginkgo biloba extract modestly lowered atorvastatin exposure, including a larger drop in peak concentration.... |
| Grapefruit Juice | Caution | Grapefruit juice inhibits intestinal CYP3A4 and can increase atorvastatin exposure, raising muscle-toxicity risk especially with large or repeated... details → |
| Tribulus Terrestris | Caution | A case report described rhabdomyolysis after Tribulus terrestris was started in a patient taking long-term atorvastatin. Causality is not proven,... |
| Vitamin B3 | Caution | High-dose niacin (>1g/day) combined with atorvastatin may increase the risk of myopathy and rhabdomyolysis. The AIM-HIGH and HPS2-THRIVE trials also... details → |
| Coenzyme Q10 | Synergy | Atorvastatin can lower circulating CoQ10 because cholesterol and CoQ10 synthesis share the mevalonate pathway. Lower CoQ10 is one proposed... details → |
| Coenzyme Q10 Ubiquinol | Synergy | Atorvastatin inhibits HMG-CoA reductase, which also reduces endogenous CoQ10 synthesis. Statin-induced CoQ10 depletion may contribute to... details → |
| Fish Oil | Synergy | Fish oil omega-3 fatty acids can add triglyceride lowering to statin therapy. Randomized studies of high-dose omega-3 fatty acids added to... details → |
| Psyllium Husk | Synergy | Psyllium husk can add LDL-lowering benefit to statin therapy through a non-statin mechanism. A randomized atorvastatin study and a statin-adjunct... details → |
What atorvastatin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Coenzyme Q10 Ubiquinol | Plasma CoQ10 |
The full atorvastatin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common atorvastatin questions.
Quick answers drawn from the tables above.
What interacts with Atorvastatin?
In the NutriStack database, Atorvastatin has 12 documented interactions. The most notable include Green Tea Extract, St. John's Wort, Berberine, Clarithromycin, and Ginkgo Biloba. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Atorvastatin?
Atorvastatin is flagged against 2 substances in the database, including Green Tea Extract and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Atorvastatin deplete any nutrients?
Atorvastatin is associated with lowering CoQ10 with prolonged use. Useful biomarkers to monitor include Plasma CoQ10. Ask your prescriber before adding any replacement supplement.
Is it safe to take Green Tea Extract with Atorvastatin?
NutriStack classifies the Green Tea Extract and Atorvastatin pairing as conflict: Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced absorption rather than... Avoid taking concentrated green tea extract at the same time as atorvastatin. If you use green tea extract regularly, keep the routine consistent... Always confirm with your prescriber.
Check your whole stack
See how atorvastatin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.