Medication·Interactions & depletion·Reviewed June 9, 2026
Captopril interactions.
Captopril has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Captopril at a glance.
A quick, data-grounded summary. The full tables are below.
Captopril has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with captopril.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Potassium | Conflict | Captopril, like other ACE inhibitors, reduces aldosterone secretion and promotes renal potassium retention, raising serum potassium. Adding a... |
| Garlic Extract | Caution | Garlic extract has modest blood-pressure-lowering properties and may add to the antihypertensive effect of captopril. While this can be beneficial,... |
| L-Citrulline | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Captopril. |
| Magnesium Glycinate | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Captopril. |
| Zinc | Caution | The sulfhydryl group of captopril chelates zinc and increases urinary zinc excretion, and long-term ACE inhibitor therapy has been associated with... |
| Iron | Timing Sensitive | Oral iron salts can react with captopril, which contains a free sulfhydryl (thiol) group, forming a complex that reduces captopril absorption and... |
What captopril can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Moderate | Captopril contains a sulfhydryl (thiol) group that chelates zinc, forming a captopril-zinc complex that increases urinary zinc excretion. Chronic... | Zinc | Serum or plasma zinc |
The full captopril profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common captopril questions.
Quick answers drawn from the tables above.
What interacts with Captopril?
In the NutriStack database, Captopril has 6 documented interactions. The most notable include Potassium, Garlic Extract, L-Citrulline, Magnesium Glycinate, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Captopril?
Captopril is flagged against 1 substance in the database, including Potassium. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Captopril deplete any nutrients?
Captopril is associated with lowering Zinc with prolonged use. Useful biomarkers to monitor include Serum or plasma zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Potassium with Captopril?
NutriStack classifies the Potassium and Captopril pairing as conflict: Captopril, like other ACE inhibitors, reduces aldosterone secretion and promotes renal potassium retention, raising serum potassium. Adding a potassium supplement (or... Avoid routine potassium supplements and potassium-based salt substitutes unless specifically prescribed and monitored. If potassium is clinically... Always confirm with your prescriber.
Check your whole stack
See how captopril fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.