Medication·Interactions & depletion·Reviewed June 9, 2026
Cefdinir interactions.
Cefdinir has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K and Iron. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Cefdinir at a glance.
A quick, data-grounded summary. The full tables are below.
Cefdinir has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K and Iron. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with cefdinir.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Timing Sensitive | High-dose calcium supplements and calcium-containing antacids can bind cefdinir in the gut and modestly reduce its absorption through... |
| Iron | Timing Sensitive | Iron can reduce oral Cefdinir absorption when taken together. |
| Magnesium Glycinate | Timing Sensitive | Magnesium Glycinate can reduce oral Cefdinir absorption when taken together. |
| Probiotics | Timing Sensitive | Cefdinir can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower antibiotic-associated... |
| Zinc | Timing Sensitive | Zinc supplements supply divalent zinc cations that can chelate cefdinir in the gastrointestinal tract by the same mechanism that drives the iron and... |
What cefdinir can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Like other broad-spectrum cephalosporins, cefdinir suppresses gut bacteria that synthesize menaquinone (vitamin K2). Reduced bacterial vitamin K... | Vitamin K2 (menaquinone) | Prothrombin time / INR (especially in patients on warfarin or with poor intake) |
| Iron | Moderate | Cefdinir is not depleted by iron, but the two form a clinically important interaction: cefdinir chelates ferrous iron in the gut to produce a... | – | Not routinely monitored; separate dosing rather than supplement |
The full cefdinir profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common cefdinir questions.
Quick answers drawn from the tables above.
What interacts with Cefdinir?
In the NutriStack database, Cefdinir has 5 documented interactions. The most notable include Calcium, Iron, Magnesium Glycinate, Probiotics, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Does Cefdinir deplete any nutrients?
Cefdinir is associated with lowering Vitamin K and Iron with prolonged use. Useful biomarkers to monitor include Prothrombin time / INR (especially in patients on warfarin or with poor intake) and Not routinely monitored; separate dosing rather than supplement. Ask your prescriber before adding any replacement supplement.
Is it safe to take Calcium with Cefdinir?
NutriStack classifies the Calcium and Cefdinir pairing as timing sensitive: High-dose calcium supplements and calcium-containing antacids can bind cefdinir in the gut and modestly reduce its absorption through divalent-cation chelation, similar... Separate calcium supplements or calcium-based antacids from cefdinir by at least 2 hours. Take cefdinir on a consistent schedule and avoid combining... Always confirm with your prescriber.
Check your whole stack
See how cefdinir fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.