Medication·Interactions & depletion·Reviewed June 9, 2026
Cefixime interactions.
Cefixime has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Cefixime at a glance.
A quick, data-grounded summary. The full tables are below.
Cefixime has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with cefixime.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin K1 | Caution | Prolonged Cefixime therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor... |
| Vitamin K2 | Caution | Broad-spectrum antibiotics including cephalosporins can suppress vitamin K-producing gut flora during prolonged or repeated courses, which may... |
| Calcium | Timing Sensitive | Calcium-containing supplements and antacids may bind cefixime in the gut, reducing its dissolution and absorption and potentially undermining... |
| Iron | Timing Sensitive | Oral iron salts can reduce the absorption of cefixime by forming poorly soluble chelates in the gastrointestinal tract, potentially lowering... |
| Probiotics | Timing Sensitive | Cefixime can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower antibiotic-associated... |
What cefixime can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum cephalosporins suppress colonic bacteria (notably Bacteroides species) that synthesize menaquinones (vitamin K2), reducing the... | Vitamin K (phylloquinone) only if clinically indicated; routine supplementation is not required for short courses | Prothrombin time / INR (particularly in patients on warfarin or with marginal vitamin K status) |
The full cefixime profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common cefixime questions.
Quick answers drawn from the tables above.
What interacts with Cefixime?
In the NutriStack database, Cefixime has 5 documented interactions. The most notable include Vitamin K1, Vitamin K2, Calcium, Iron, and Probiotics. Check any specific combination before taking it and confirm with your prescriber.
Does Cefixime deplete any nutrients?
Cefixime is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include Prothrombin time / INR (particularly in patients on warfarin or with marginal vitamin K status). Ask your prescriber before adding any replacement supplement.
Is it safe to take Vitamin K1 with Cefixime?
NutriStack classifies the Vitamin K1 and Cefixime pairing as caution: Prolonged Cefixime therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor intake, malabsorption,... Do not self-treat bleeding or INR changes. Monitor for bruising or bleeding and coordinate vitamin K or anticoagulant changes with the prescriber. Always confirm with your prescriber.
Check your whole stack
See how cefixime fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.