Medication·Interactions & depletion·Reviewed June 9, 2026
Cefuroxime interactions.
Cefuroxime has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Cefuroxime at a glance.
A quick, data-grounded summary. The full tables are below.
Cefuroxime has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with cefuroxime.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin K1 | Caution | Prolonged Cefuroxime therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor... |
| Calcium | Timing Sensitive | Calcium-containing supplements and antacids can chelate cefuroxime and raise gastric pH. Because cefuroxime axetil relies on an acidic stomach... |
| Iron | Timing Sensitive | Oral iron salts can form insoluble chelates with cephalosporin antibiotics and may also raise gastric pH, both of which can reduce the absorption... |
| Probiotics | Timing Sensitive | Cefuroxime can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower... |
| Zinc | Timing Sensitive | Oral zinc, a divalent cation, can chelate cephalosporins and reduce their gastrointestinal absorption. Although best characterized for quinolone and... |
What cefuroxime can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum antibiotic suppression of vitamin K-producing colonic bacteria reduces the supply of menaquinones (vitamin K2). Unlike cephalosporins... | Vitamin K1 (phylloquinone) | Prothrombin time / INR (consider in malnourished or anticoagulated patients on prolonged therapy) |
The full cefuroxime profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common cefuroxime questions.
Quick answers drawn from the tables above.
What interacts with Cefuroxime?
In the NutriStack database, Cefuroxime has 5 documented interactions. The most notable include Vitamin K1, Calcium, Iron, Probiotics, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Does Cefuroxime deplete any nutrients?
Cefuroxime is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include Prothrombin time / INR (consider in malnourished or anticoagulated patients on prolonged therapy). Ask your prescriber before adding any replacement supplement.
Is it safe to take Vitamin K1 with Cefuroxime?
NutriStack classifies the Vitamin K1 and Cefuroxime pairing as caution: Prolonged Cefuroxime therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor intake,... Do not self-treat bleeding or INR changes. Monitor for bruising or bleeding and coordinate vitamin K or anticoagulant changes with the prescriber. Always confirm with your prescriber.
Check your whole stack
See how cefuroxime fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.