Medication·Interactions & depletion·Reviewed June 9, 2026
Chlorthalidone interactions.
Chlorthalidone has 11 documented interactions in the NutriStack database. Prolonged use is also associated with lower Potassium, Magnesium, Zinc, and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Chlorthalidone at a glance.
A quick, data-grounded summary. The full tables are below.
Chlorthalidone has 11 documented interactions in the NutriStack database. Prolonged use is also associated with lower Potassium, Magnesium, Zinc, and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with chlorthalidone.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Alcohol | Caution | Chlorthalidone has a long duration of action and can cause volume depletion, low sodium, and low potassium. Alcohol can worsen orthostatic... details → |
| Calcium | Caution | Chlorthalidone is thiazide-like and reduces urinary calcium loss, which can raise serum calcium. High-dose calcium supplements can add to that... details → |
| L-Arginine | Caution | L-Arginine can lower blood pressure, and chlorthalidone is a long-acting antihypertensive diuretic. Combining them can produce additive... details → |
| L-Citrulline | Caution | L-Citrulline can modestly lower blood pressure through the arginine-nitric oxide pathway. Chlorthalidone has sustained antihypertensive and diuretic... details → |
| Vitamin D2 | Caution | Chlorthalidone reduces urinary calcium excretion, and Vitamin D2 can increase calcium absorption after metabolic activation. High-dose Vitamin D2... |
| Vitamin D3 | Caution | Chlorthalidone can increase serum calcium by lowering urinary calcium excretion, while Vitamin D3 increases intestinal calcium absorption. Usual... details → |
| Magnesium Citrate | Synergy | Chlorthalidone can cause magnesium depletion during long-term treatment. Magnesium citrate may help replenish magnesium, particularly when potassium... details → |
| Magnesium Glycinate | Synergy | Long-term chlorthalidone therapy can lower magnesium as well as potassium. Magnesium glycinate may help replace magnesium when levels are low or... details → |
| Magnesium Malate | Synergy | Chlorthalidone has documented potential to lower magnesium during chronic treatment. Magnesium malate is a magnesium-containing supplement that can... details → |
| Magnesium Taurate | Synergy | Chlorthalidone can lower magnesium and potassium during long-term use. Magnesium taurate may help replenish magnesium stores if supplementation is... details → |
| Potassium | Synergy | Chlorthalidone commonly lowers serum potassium through renal potassium wasting. Potassium supplementation can be clinically useful when levels are... details → |
What chlorthalidone can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Potassium | Moderate | Thiazide diuresis can increase distal sodium delivery and urinary potassium secretion, so potassium should be monitored rather than self-repleted. | Clinician-guided potassium repletion if serum potassium is low | Serum potassium + kidney function |
| Magnesium | Moderate | Thiazides can increase urinary magnesium losses and contribute to low magnesium status. | Magnesium Glycinate | Serum magnesium or RBC magnesium |
| Zinc | Mild | Chronic thiazide use can increase urinary zinc excretion and gradually lower zinc balance. | Zinc Picolinate | Serum zinc |
| Sodium | Moderate | Thiazides are a common medication cause of hyponatremia, especially in older adults. | – | Serum sodium |
| CoQ10 | Mild | Beta-blocker and diuretic therapy are associated with lower CoQ10 status in some long-term users, likely through increased oxidative demand and... | Coenzyme Q10 | Plasma CoQ10 |
The full chlorthalidone profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common chlorthalidone questions.
Quick answers drawn from the tables above.
What interacts with Chlorthalidone?
In the NutriStack database, Chlorthalidone has 11 documented interactions. The most notable include Alcohol, Calcium, L-Arginine, L-Citrulline, and Vitamin D2. Check any specific combination before taking it and confirm with your prescriber.
Does Chlorthalidone deplete any nutrients?
Chlorthalidone is associated with lowering Potassium, Magnesium, Zinc, Sodium, and CoQ10 with prolonged use. Useful biomarkers to monitor include Serum potassium + kidney function, Serum magnesium or RBC magnesium, and Serum zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Alcohol with Chlorthalidone?
NutriStack classifies the Alcohol and Chlorthalidone pairing as caution: Chlorthalidone has a long duration of action and can cause volume depletion, low sodium, and low potassium. Alcohol can worsen orthostatic hypotension and dehydration,... Limit alcohol while taking chlorthalidone, particularly during the first weeks of therapy or after dose changes. Maintain appropriate hydration,... Always confirm with your prescriber.
Check your whole stack
See how chlorthalidone fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.