Medication·Interactions & depletion·Reviewed June 9, 2026
Clindamycin interactions.
Clindamycin has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Clindamycin at a glance.
A quick, data-grounded summary. The full tables are below.
Clindamycin has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with clindamycin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Lactobacillus Rhamnosus | Synergy | Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea during clindamycin therapy, which carries one of the highest baseline rates of AAD... details → |
| Probiotics | Synergy | Clindamycin is one of the highest-risk antibiotics for C. difficile-associated colitis. Probiotic supplementation during clindamycin therapy reduces... details → |
| Saccharomyces Boulardii | Synergy | Clindamycin carries one of the highest risks of C. difficile-associated colitis among commonly used antibiotics. Saccharomyces boulardii has strong... details → |
What clindamycin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Broad-spectrum antibiotic exposure can suppress gut bacteria that synthesize menaquinones, lowering vitamin K availability in susceptible patients. | – | PT/INR |
The full clindamycin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common clindamycin questions.
Quick answers drawn from the tables above.
What interacts with Clindamycin?
In the NutriStack database, Clindamycin has 3 documented interactions. The most notable include Lactobacillus Rhamnosus, Probiotics, and Saccharomyces Boulardii. Check any specific combination before taking it and confirm with your prescriber.
Does Clindamycin deplete any nutrients?
Clindamycin is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include PT/INR. Ask your prescriber before adding any replacement supplement.
Is it safe to take Lactobacillus Rhamnosus with Clindamycin?
NutriStack classifies the Lactobacillus Rhamnosus and Clindamycin pairing as synergy: Lactobacillus rhamnosus GG reduces antibiotic-associated diarrhea during clindamycin therapy, which carries one of the highest baseline rates of AAD and C. difficile... Strongly consider Lactobacillus rhamnosus throughout your clindamycin course, separated by at least 2 hours from each antibiotic dose. Continue for... Always confirm with your prescriber.
Check your whole stack
See how clindamycin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.