Medication·Interactions & depletion·Reviewed June 9, 2026
Cyclosporine interactions.
Cyclosporine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Cyclosporine at a glance.
A quick, data-grounded summary. The full tables are below.
Cyclosporine has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with cyclosporine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| St. John's Wort | Contraindicated | St. John's Wort can markedly reduce cyclosporine concentrations and has been associated with transplant rejection. |
| Berberine | Caution | Berberine may affect P-glycoprotein and CYP3A pathways and could alter cyclosporine levels. |
| Potassium | Caution | Cyclosporine can cause hyperkalemia; potassium supplements or salt substitutes can make it dangerous. |
| Quercetin | Caution | Quercetin may inhibit CYP3A4 or P-glycoprotein and could increase cyclosporine exposure and nephrotoxicity. |
| Magnesium Glycinate | Synergy | Magnesium may help correct cyclosporine-associated hypomagnesemia, but kidney function and levels must guide dosing. |
What cyclosporine can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Magnesium | Significant | Calcineurin inhibitors can cause renal magnesium wasting and hypomagnesemia. | Magnesium Glycinate | Serum magnesium |
The full cyclosporine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common cyclosporine questions.
Quick answers drawn from the tables above.
What interacts with Cyclosporine?
In the NutriStack database, Cyclosporine has 5 documented interactions. The most notable include St. John's Wort, Berberine, Potassium, Quercetin, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Cyclosporine?
Cyclosporine is flagged against 1 substance in the database, including St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Cyclosporine deplete any nutrients?
Cyclosporine is associated with lowering Magnesium with prolonged use. Useful biomarkers to monitor include Serum magnesium. Ask your prescriber before adding any replacement supplement.
Is it safe to take St. John's Wort with Cyclosporine?
NutriStack classifies the St. John's Wort and Cyclosporine pairing as contraindicated: St. John's Wort can markedly reduce cyclosporine concentrations and has been associated with transplant rejection. Avoid completely unless a transplant specialist explicitly directs otherwise. Always confirm with your prescriber.
Check your whole stack
See how cyclosporine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.