Medication·Interactions & depletion·Reviewed June 9, 2026
Dicloxacillin interactions.
Dicloxacillin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Dicloxacillin at a glance.
A quick, data-grounded summary. The full tables are below.
Dicloxacillin has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin K. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with dicloxacillin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin K1 | Caution | Prolonged Dicloxacillin therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in... |
| Vitamin K2 | Caution | Broad-spectrum and beta-lactam antibiotics can disrupt gut flora that synthesize vitamin K, theoretically reducing endogenous vitamin K... |
| Calcium | Timing Sensitive | Calcium supplements and calcium-rich products can bind oral penicillins in the gastrointestinal tract and, together with food, reduce dicloxacillin... |
| Probiotics | Timing Sensitive | Dicloxacillin can suppress or kill bacterial probiotic organisms if taken at the same time, although selected probiotics may lower... |
| Zinc | Timing Sensitive | Oral zinc can form poorly absorbed complexes with beta-lactam antibiotics. Although best characterized for the antipseudomonal penicillins and for... |
What dicloxacillin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin K | Mild | Like other broad-acting oral antibiotics, dicloxacillin can suppress vitamin K-producing (menaquinone-synthesizing) gut bacteria in the colon. In... | – | Prothrombin time / INR (especially in patients taking warfarin) |
The full dicloxacillin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common dicloxacillin questions.
Quick answers drawn from the tables above.
What interacts with Dicloxacillin?
In the NutriStack database, Dicloxacillin has 5 documented interactions. The most notable include Vitamin K1, Vitamin K2, Calcium, Probiotics, and Zinc. Check any specific combination before taking it and confirm with your prescriber.
Does Dicloxacillin deplete any nutrients?
Dicloxacillin is associated with lowering Vitamin K with prolonged use. Useful biomarkers to monitor include Prothrombin time / INR (especially in patients taking warfarin). Ask your prescriber before adding any replacement supplement.
Is it safe to take Vitamin K1 with Dicloxacillin?
NutriStack classifies the Vitamin K1 and Dicloxacillin pairing as caution: Prolonged Dicloxacillin therapy can contribute to reduced vitamin K status in susceptible patients by altering gut flora, with higher concern in poor intake,... Do not self-treat bleeding or INR changes. Monitor for bruising or bleeding and coordinate vitamin K or anticoagulant changes with the prescriber. Always confirm with your prescriber.
Check your whole stack
See how dicloxacillin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.