Medication·Interactions & depletion·Reviewed June 9, 2026
Duloxetine interactions.
Duloxetine has 6 documented interactions in the NutriStack database, including 4 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Duloxetine at a glance.
A quick, data-grounded summary. The full tables are below.
Duloxetine has 6 documented interactions in the NutriStack database, including 4 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with duloxetine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that potently blocks serotonin reuptake. Adding 5-HTP, a direct serotonin... details → |
| L-Tryptophan | Contraindicated | Duloxetine blocks both serotonin and norepinephrine reuptake, and L-tryptophan provides extra substrate for serotonin synthesis. The combination can... details → |
| MDMA | Contraindicated | Duloxetine directly interferes with MDMA pharmacology at serotonin and norepinephrine transporters. In a controlled human study, duloxetine reduced... details → |
| St. John's Wort | Contraindicated | Combining duloxetine (an SNRI) with St. John's Wort creates a serious risk of serotonin syndrome. Both agents increase synaptic serotonin through... details → |
| Alcohol | Caution | Duloxetine has a known rare risk of clinically significant liver injury, and substantial alcohol use is a recognized risk factor in labeling and... details → |
| SAMe | Caution | SAMe has antidepressant and monoamine-modulating activity. Duloxetine increases serotonin and norepinephrine signaling, so adding SAMe may increase... |
What duloxetine can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Sodium | Moderate | Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia. | – | Serum sodium |
The full duloxetine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common duloxetine questions.
Quick answers drawn from the tables above.
What interacts with Duloxetine?
In the NutriStack database, Duloxetine has 6 documented interactions. The most notable include 5-HTP, L-Tryptophan, MDMA, St. John's Wort, and Alcohol. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Duloxetine?
Duloxetine is flagged against 4 substances in the database, including 5-HTP, L-Tryptophan, MDMA, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Duloxetine deplete any nutrients?
Duloxetine is associated with lowering Sodium with prolonged use. Useful biomarkers to monitor include Serum sodium. Ask your prescriber before adding any replacement supplement.
Is it safe to take 5-HTP with Duloxetine?
NutriStack classifies the 5-HTP and Duloxetine pairing as contraindicated: Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that potently blocks serotonin reuptake. Adding 5-HTP, a direct serotonin precursor, significantly... Do not combine 5-HTP with duloxetine. The risk of serotonin syndrome is significant with this combination. If you are taking 5-HTP, discontinue it... Always confirm with your prescriber.
Check your whole stack
See how duloxetine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.