Medication·Interactions & depletion·Reviewed June 9, 2026
Ezetimibe interactions.
Ezetimibe has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin E and Beta-carotene. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Ezetimibe at a glance.
A quick, data-grounded summary. The full tables are below.
Ezetimibe has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Vitamin E and Beta-carotene. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with ezetimibe.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Vitamin D3 | Caution | Ezetimibe blocks intestinal absorption of cholesterol via the Niemann-Pick C1-Like 1 (NPC1L1) transporter. Because fat-soluble vitamin D shares a... |
| Vitamin E | Caution | As a fat-soluble vitamin absorbed through the same micellar lipid pathway affected by ezetimibe, vitamin E (tocopherol) absorption may be modestly... |
| Psyllium Husk | Timing Sensitive | Psyllium can delay or reduce absorption of some oral drugs if taken at the same time as Ezetimibe. |
| Berberine | Synergy | Berberine may add modest lipid-lowering effects to Ezetimibe. |
| Fish Oil | Synergy | Fish oil (EPA and DHA) primarily lowers triglycerides and modestly affects other lipid fractions through mechanisms distinct from ezetimibe's... |
What ezetimibe can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin E | Mild | Ezetimibe inhibits the intestinal sterol transporter NPC1L1 at the brush border of enterocytes, reducing absorption of dietary and biliary... | Vitamin E (mixed tocopherols) | Serum alpha-tocopherol, ideally expressed per mmol of total cholesterol plus triglycerides (lipid-standardized) |
| Beta-carotene | Mild | Carotenoids are absorbed in the intestine through lipid micelles and partly via NPC1L1-mediated and scavenger-receptor pathways shared with... | Beta-carotene (or a mixed-carotenoid/vitamin A supplement) | Plasma beta-carotene (lipid-standardized) or serum retinol if clinical deficiency is suspected |
The full ezetimibe profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ezetimibe questions.
Quick answers drawn from the tables above.
What interacts with Ezetimibe?
In the NutriStack database, Ezetimibe has 5 documented interactions. The most notable include Vitamin D3, Vitamin E, Psyllium Husk, Berberine, and Fish Oil. Check any specific combination before taking it and confirm with your prescriber.
Does Ezetimibe deplete any nutrients?
Ezetimibe is associated with lowering Vitamin E and Beta-carotene with prolonged use. Useful biomarkers to monitor include Serum alpha-tocopherol, ideally expressed per mmol of total cholesterol plus triglycerides (lipid-standardized) and Plasma beta-carotene (lipid-standardized) or serum retinol if clinical deficiency is suspected. Ask your prescriber before adding any replacement supplement.
Is it safe to take Vitamin D3 with Ezetimibe?
NutriStack classifies the Vitamin D3 and Ezetimibe pairing as caution: Ezetimibe blocks intestinal absorption of cholesterol via the Niemann-Pick C1-Like 1 (NPC1L1) transporter. Because fat-soluble vitamin D shares a dependence on intact... Routine vitamin D3 supplementation does not need to be stopped. For patients on long-term ezetimibe, especially those with baseline insufficiency,... Always confirm with your prescriber.
Check your whole stack
See how ezetimibe fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.