Medication·Interactions & depletion·Reviewed June 9, 2026
Fenofibrate interactions.
Fenofibrate has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10 and Vitamin E. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Fenofibrate at a glance.
A quick, data-grounded summary. The full tables are below.
Fenofibrate has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10 and Vitamin E. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with fenofibrate.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Garlic Extract | Caution | Fenofibrate has antiplatelet-like effects and is reported to potentiate the action of anticoagulants. Concentrated garlic extract has mild... |
| Milk Thistle | Caution | Fenofibrate can elevate liver transaminases and, rarely, cause hepatotoxicity. Milk thistle (silymarin) is taken for liver support but can mask or... |
| Coenzyme Q10 | Timing Sensitive | Fibrates, like statins, may modestly lower endogenous coenzyme Q10 (ubiquinone) levels, and myopathy risk rises when fenofibrate is combined with a... |
| Berberine | Synergy | Berberine may add modest lipid-lowering effects to Fenofibrate. |
| Fish Oil | Synergy | Fish Oil may add modest lipid-lowering effects to Fenofibrate for triglyceride lowering. |
What fenofibrate can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Coenzyme Q10 | Mild | Fibrates inhibit HMG-CoA reductase activity indirectly and reduce mevalonate pathway flux similar to (though more weakly than) statins, lowering... | Coenzyme Q10 (ubiquinone) | Plasma/serum CoQ10 (rarely measured clinically); monitor for myalgia and serum creatine kinase if myopathy suspected |
| Vitamin E | Mild | Fenofibrate lowers circulating lipoproteins (VLDL and LDL) that transport fat-soluble vitamin E (tocopherols) in plasma. Because measured serum... | Vitamin E (mixed tocopherols) only if a documented deficiency is confirmed | Serum alpha-tocopherol, ideally interpreted relative to serum lipids (tocopherol-to-cholesterol ratio) |
The full fenofibrate profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common fenofibrate questions.
Quick answers drawn from the tables above.
What interacts with Fenofibrate?
In the NutriStack database, Fenofibrate has 5 documented interactions. The most notable include Garlic Extract, Milk Thistle, Coenzyme Q10, Berberine, and Fish Oil. Check any specific combination before taking it and confirm with your prescriber.
Does Fenofibrate deplete any nutrients?
Fenofibrate is associated with lowering Coenzyme Q10 and Vitamin E with prolonged use. Useful biomarkers to monitor include Plasma/serum CoQ10 (rarely measured clinically); monitor for myalgia and serum creatine kinase if myopathy suspected and Serum alpha-tocopherol, ideally interpreted relative to serum lipids (tocopherol-to-cholesterol ratio). Ask your prescriber before adding any replacement supplement.
Is it safe to take Garlic Extract with Fenofibrate?
NutriStack classifies the Garlic Extract and Fenofibrate pairing as caution: Fenofibrate has antiplatelet-like effects and is reported to potentiate the action of anticoagulants. Concentrated garlic extract has mild antiplatelet activity, so... Use concentrated garlic supplements cautiously with fenofibrate, especially around surgery or alongside anticoagulant/antiplatelet therapy. Watch... Always confirm with your prescriber.
Check your whole stack
See how fenofibrate fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.