Medication·Interactions & depletion·Reviewed June 9, 2026
Fluvoxamine interactions.
Fluvoxamine has 7 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Fluvoxamine at a glance.
A quick, data-grounded summary. The full tables are below.
Fluvoxamine has 7 documented interactions in the NutriStack database, including 3 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Sodium and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with fluvoxamine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP is the immediate precursor to serotonin and bypasses the rate-limiting step in serotonin synthesis. Combined with fluvoxamine's blockade of... details → |
| L-Tryptophan | Contraindicated | L-Tryptophan is the upstream precursor to serotonin; combined with fluvoxamine's serotonin reuptake blockade, it can drive synaptic serotonin to... details → |
| St. John's Wort | Contraindicated | St. John's Wort has SSRI-like activity and is a strong CYP3A4/2C9 inducer. Combined with fluvoxamine, the additive serotonergic load can trigger... details → |
| Ginkgo Biloba | Caution | Fluvoxamine impairs platelet aggregation by depleting platelet serotonin; Ginkgo's ginkgolides inhibit platelet-activating factor. Combined... details → |
| Green Tea Extract | Caution | Fluvoxamine is a potent CYP1A2 inhibitor, and the caffeine in green tea extracts is metabolized almost entirely by CYP1A2. In healthy volunteers,... details → |
| Melatonin | Caution | Fluvoxamine is a potent CYP1A2 inhibitor, and melatonin is metabolized almost entirely by CYP1A2. Coadministration raises melatonin AUC about... details → |
| SAMe | Caution | SAMe has independent serotonergic and antidepressant activity. Combined with fluvoxamine, the additive serotonergic load raises the risk of... |
What fluvoxamine can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Sodium | Significant | SSRI-induced SIADH can lower serum sodium, especially in older adults and during the first weeks of therapy. | – | Serum sodium |
| Folate | Mild | Lower folate status is associated with poorer SSRI response and may be reduced in some chronic users through altered one-carbon metabolism. | Methylfolate | Serum folate or RBC folate |
The full fluvoxamine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common fluvoxamine questions.
Quick answers drawn from the tables above.
What interacts with Fluvoxamine?
In the NutriStack database, Fluvoxamine has 7 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, Ginkgo Biloba, and Green Tea Extract. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Fluvoxamine?
Fluvoxamine is flagged against 3 substances in the database, including 5-HTP, L-Tryptophan, and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Fluvoxamine deplete any nutrients?
Fluvoxamine is associated with lowering Sodium and Folate with prolonged use. Useful biomarkers to monitor include Serum sodium and Serum folate or RBC folate. Ask your prescriber before adding any replacement supplement.
Is it safe to take 5-HTP with Fluvoxamine?
NutriStack classifies the 5-HTP and Fluvoxamine pairing as contraindicated: 5-HTP is the immediate precursor to serotonin and bypasses the rate-limiting step in serotonin synthesis. Combined with fluvoxamine's blockade of the serotonin... Do not take 5-HTP with fluvoxamine. If you have been taking 5-HTP, stop it before starting fluvoxamine and stay off it throughout treatment. Always confirm with your prescriber.
Check your whole stack
See how fluvoxamine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.