Medication·Interactions & depletion·Reviewed June 9, 2026
Gemfibrozil interactions.
Gemfibrozil has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10 and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Gemfibrozil at a glance.
A quick, data-grounded summary. The full tables are below.
Gemfibrozil has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10 and Folate. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with gemfibrozil.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Berberine has lipid-lowering and glucose-lowering activity and modulates several drug-metabolizing enzymes and transporters (including CYP3A4 and... |
| Coenzyme Q10 | Caution | Gemfibrozil, like statins and other fibrates, can lower circulating coenzyme Q10 (ubiquinone) concentrations and is associated with muscle-related... |
| Fish Oil | Caution | High-dose omega-3 fatty acids (EPA/DHA) and gemfibrozil are both used to lower triglycerides and are sometimes co-prescribed. Each can modestly... |
| Vitamin E | Caution | High-dose vitamin E has antiplatelet/anticoagulant properties and can potentiate bleeding risk. Gemfibrozil itself can potentiate oral... |
What gemfibrozil can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Coenzyme Q10 | Mild | Fibrates lower circulating cholesterol and lipoproteins, which serve as the principal transport vehicles for the lipophilic,... | Coenzyme Q10 (ubiquinone) | Plasma coenzyme Q10 level (interpret relative to total cholesterol/LDL, as CoQ10 tracks with lipoprotein concentration); creatine kinase if myopathy is suspected |
| Folate | Mild | Fibrate therapy is associated with an increase in plasma total homocysteine, an effect attributed largely to altered renal handling/creatinine and... | Folic acid (or L-methylfolate) | Plasma total homocysteine; serum/red blood cell folate |
The full gemfibrozil profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common gemfibrozil questions.
Quick answers drawn from the tables above.
What interacts with Gemfibrozil?
In the NutriStack database, Gemfibrozil has 4 documented interactions. The most notable include Berberine, Coenzyme Q10, Fish Oil, and Vitamin E. Check any specific combination before taking it and confirm with your prescriber.
Does Gemfibrozil deplete any nutrients?
Gemfibrozil is associated with lowering Coenzyme Q10 and Folate with prolonged use. Useful biomarkers to monitor include Plasma coenzyme Q10 level (interpret relative to total cholesterol/LDL, as CoQ10 tracks with lipoprotein concentration); creatine kinase if myopathy is suspected and Plasma total homocysteine; serum/red blood cell folate. Ask your prescriber before adding any replacement supplement.
Is it safe to take Berberine with Gemfibrozil?
NutriStack classifies the Berberine and Gemfibrozil pairing as caution: Berberine has lipid-lowering and glucose-lowering activity and modulates several drug-metabolizing enzymes and transporters (including CYP3A4 and CYP2D6 inhibition).... Use berberine cautiously with gemfibrozil. Discuss with a clinician before combining, particularly if also taking statins, antidiabetic drugs, or... Always confirm with your prescriber.
Check your whole stack
See how gemfibrozil fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.