Medication·Interactions & depletion·Reviewed June 9, 2026
Labetalol interactions.
Labetalol has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Labetalol at a glance.
A quick, data-grounded summary. The full tables are below.
Labetalol has 3 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with labetalol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Berberine may lower glucose, while beta blockers can mask adrenergic warning signs of hypoglycemia such as tachycardia. |
| L-Citrulline | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Labetalol. |
| Magnesium Glycinate | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Labetalol. |
What labetalol can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Coenzyme Q10 | Mild | Like other beta-adrenergic blocking agents, labetalol can inhibit Coenzyme Q10 (ubiquinone)-dependent enzymes and reduce CoQ10-related mitochondrial... | Coenzyme Q10 (ubiquinone or ubiquinol) | Plasma Coenzyme Q10 concentration (not routinely measured clinically) |
The full labetalol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common labetalol questions.
Quick answers drawn from the tables above.
What interacts with Labetalol?
In the NutriStack database, Labetalol has 3 documented interactions. The most notable include Berberine, L-Citrulline, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Does Labetalol deplete any nutrients?
Labetalol is associated with lowering Coenzyme Q10 with prolonged use. Useful biomarkers to monitor include Plasma Coenzyme Q10 concentration (not routinely measured clinically). Ask your prescriber before adding any replacement supplement.
Is it safe to take Berberine with Labetalol?
NutriStack classifies the Berberine and Labetalol pairing as caution: Berberine may lower glucose, while beta blockers can mask adrenergic warning signs of hypoglycemia such as tachycardia. Use glucose monitoring if diabetic or taking glucose-lowering drugs; do not rely only on palpitations as a hypoglycemia warning sign. Always confirm with your prescriber.
Check your whole stack
See how labetalol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.