Medication·Interactions & depletion·Reviewed June 9, 2026
Lansoprazole interactions.
Lansoprazole has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Vitamin B12, Calcium, and Iron. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Lansoprazole at a glance.
A quick, data-grounded summary. The full tables are below.
Lansoprazole has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Vitamin B12, Calcium, and Iron. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with lansoprazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Caution | Lansoprazole reduces absorption of calcium carbonate, which depends on stomach acid for dissolution. Long-term PPI use is associated with a modest... details → |
| Iron | Caution | Lansoprazole reduces absorption of non-heme iron salts that require gastric acid for dissolution. The Kaiser study of 77,000 iron-deficiency cases... details → |
| Magnesium Glycinate | Caution | Lansoprazole, like other PPIs, can cause hypomagnesemia after months to years of use. Case reports and meta-analyses confirm reduced intestinal... details → |
| Vitamin B12 | Caution | Lansoprazole reduces vitamin B12 absorption from food over years of use. The Kaiser Permanente case-control study linked two or more years of any... details → |
| Vitamin C | Caution | Lansoprazole reduces the bioavailability of dietary vitamin C by raising intragastric pH, which destabilizes ascorbate. A four-week trial of a PPI... details → |
| Zinc | Caution | Long-term lansoprazole therapy reduces zinc absorption and lowers body zinc stores. Controlled data on PPI users showed plasma zinc rose only 37%... details → |
What lansoprazole can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Magnesium | Significant | Chronic acid suppression impairs active intestinal magnesium transport, especially via TRPM6/7-mediated uptake. | Magnesium Glycinate | Serum magnesium or RBC magnesium |
| Vitamin B12 | Moderate | Reduced gastric acid impairs release of food-bound vitamin B12 from proteins, lowering long-term absorption. | Methylcobalamin | Serum B12 + methylmalonic acid |
| Calcium | Moderate | Lower gastric acidity reduces dissolution and absorption of less-soluble calcium salts, especially calcium carbonate. | Calcium | Serum calcium or bone density trend |
| Iron | Moderate | Reduced gastric acidity lowers conversion and solubility of non-heme iron, decreasing long-term absorption. | Iron Bisglycinate | Ferritin + transferrin saturation |
The full lansoprazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common lansoprazole questions.
Quick answers drawn from the tables above.
What interacts with Lansoprazole?
In the NutriStack database, Lansoprazole has 6 documented interactions. The most notable include Calcium, Iron, Magnesium Glycinate, Vitamin B12, and Vitamin C. Check any specific combination before taking it and confirm with your prescriber.
Does Lansoprazole deplete any nutrients?
Lansoprazole is associated with lowering Magnesium, Vitamin B12, Calcium, and Iron with prolonged use. Useful biomarkers to monitor include Serum magnesium or RBC magnesium, Serum B12 + methylmalonic acid, and Serum calcium or bone density trend. Ask your prescriber before adding any replacement supplement.
Is it safe to take Calcium with Lansoprazole?
NutriStack classifies the Calcium and Lansoprazole pairing as caution: Lansoprazole reduces absorption of calcium carbonate, which depends on stomach acid for dissolution. Long-term PPI use is associated with a modest but consistent rise... If you take lansoprazole long-term and need calcium, choose calcium citrate, which absorbs well without gastric acid. If using calcium carbonate,... Always confirm with your prescriber.
Check your whole stack
See how lansoprazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.