Medication·Interactions & depletion·Reviewed June 9, 2026
Levofloxacin interactions.
Levofloxacin has 10 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Levofloxacin at a glance.
A quick, data-grounded summary. The full tables are below.
Levofloxacin has 10 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with levofloxacin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Aluminum/Magnesium Hydroxide | Timing Sensitive | Aluminum and magnesium in antacids form insoluble chelate complexes with levofloxacin in the gut, reducing antibiotic absorption by 50 percent or... details → |
| Calcium | Timing Sensitive | Calcium binds levofloxacin in the gut and reduces its absorption by 30 to 50 percent. This applies to calcium supplements, calcium-fortified foods,... details → |
| Calcium Carbonate | Timing Sensitive | Calcium carbonate binds levofloxacin in the gut and reduces its absorption substantially. This applies whether calcium carbonate is taken as an... details → |
| Iron | Timing Sensitive | Iron supplements bind levofloxacin in the gut, forming insoluble chelate complexes that dramatically reduce antibiotic absorption. Bioavailability... details → |
| Iron Bisglycinate | Timing Sensitive | Iron bisglycinate, despite being a chelated and gentler form, still releases iron available for fluoroquinolone chelation in the gut.... details → |
| Magnesium Glycinate | Timing Sensitive | Magnesium glycinate chelates levofloxacin in the gut, dramatically reducing antibiotic absorption. The bioavailability decrease can exceed 40... details → |
| Manganese | Timing Sensitive | Levofloxacin can chelate with multivalent cations. PubMed-indexed in vitro work found complex formation between levofloxacin and a... details → |
| Zinc | Timing Sensitive | Zinc supplements bind levofloxacin in the gut and reduce its absorption by approximately 20 to 50 percent. Reduced antibiotic exposure can cause... details → |
| Zinc Picolinate | Timing Sensitive | Zinc picolinate can bind fluoroquinolone antibiotics in the gut and reduce absorption. Levofloxacin exposure can fall when taken with multivalent... details → |
| Probiotics | Synergy | Probiotic supplementation during levofloxacin therapy reduces the incidence of antibiotic-associated diarrhea and helps preserve gut microbiome... details → |
What levofloxacin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Magnesium | Moderate | Fluoroquinolones can increase renal magnesium wasting and can also bind supplemental magnesium in the gut during active treatment. | Magnesium Glycinate | Serum magnesium or RBC magnesium |
The full levofloxacin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common levofloxacin questions.
Quick answers drawn from the tables above.
What interacts with Levofloxacin?
In the NutriStack database, Levofloxacin has 10 documented interactions. The most notable include Aluminum/Magnesium Hydroxide, Calcium, Calcium Carbonate, Iron, and Iron Bisglycinate. Check any specific combination before taking it and confirm with your prescriber.
Does Levofloxacin deplete any nutrients?
Levofloxacin is associated with lowering Magnesium with prolonged use. Useful biomarkers to monitor include Serum magnesium or RBC magnesium. Ask your prescriber before adding any replacement supplement.
Is it safe to take Aluminum/Magnesium Hydroxide with Levofloxacin?
NutriStack classifies the Aluminum/Magnesium Hydroxide and Levofloxacin pairing as timing sensitive: Aluminum and magnesium in antacids form insoluble chelate complexes with levofloxacin in the gut, reducing antibiotic absorption by 50 percent or more. This is one of... Take levofloxacin at least 2 hours before or 2 hours after any aluminum or magnesium hydroxide antacid. Do not co-administer in the same dose. Always confirm with your prescriber.
Check your whole stack
See how levofloxacin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.