Medication·Interactions & depletion·Reviewed June 9, 2026
Losartan interactions.
Losartan has 10 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Losartan at a glance.
A quick, data-grounded summary. The full tables are below.
Losartan has 10 documented interactions in the NutriStack database, including 2 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with losartan.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Potassium | Conflict | Losartan blocks angiotensin II type 1 receptors, reducing aldosterone secretion and thereby decreasing renal potassium excretion. Adding potassium... details → |
| St. John's Wort | Conflict | Losartan is a prodrug metabolized by CYP2C9 and CYP3A4 to its active metabolite E-3174, which is 10-40 times more potent than the parent compound.... details → |
| Berberine | Caution | Berberine can inhibit CYP2C9 activity and may alter losartan conversion to its active metabolite E-3174. Berberine may also lower blood pressure, so... details → |
| Berberine HCl | Caution | Berberine HCl can inhibit CYP2C9 activity and may alter losartan conversion to its active metabolite E-3174. Berberine HCl may also lower blood... details → |
| Lithium Orotate | Caution | Losartan blocks the AT1 receptor and reduces sodium reabsorption, which causes the kidney to retain lithium. A published case described a previously... details → |
| Zinc | Caution | A systematic review of antihypertensive therapy and zinc identified increased urinary zinc loss in losartan-treated patients. The effect is smaller... |
| Fish Oil | Synergy | Fish Oil reduces blood pressure modestly and has independent renoprotective effects through reduced angiotensin II generation and downregulation of... details → |
| Garlic Extract | Synergy | Garlic Extract lowers blood pressure modestly (approximately 4-10 mm Hg systolic in hypertensives). When combined with the ARB losartan, the effects... details → |
| Magnesium Citrate | Synergy | Magnesium supplementation lowers blood pressure modestly (about 2-3 mm Hg systolic and 2 mm Hg diastolic) when added to antihypertensive medication.... details → |
| Vitamin D3 | Synergy | Vitamin D directly suppresses renin biosynthesis, so vitamin D deficiency leaves the renin-angiotensin system over-activated. Correcting deficiency... details → |
What losartan can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Mild | ARB therapy can modestly increase urinary zinc losses in some users, though typically less than ACE inhibitors. | Zinc Picolinate | Serum zinc |
The full losartan profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common losartan questions.
Quick answers drawn from the tables above.
What interacts with Losartan?
In the NutriStack database, Losartan has 10 documented interactions. The most notable include Potassium, St. John's Wort, Berberine, Berberine HCl, and Lithium Orotate. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Losartan?
Losartan is flagged against 2 substances in the database, including Potassium and St. John's Wort. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Losartan deplete any nutrients?
Losartan is associated with lowering Zinc with prolonged use. Useful biomarkers to monitor include Serum zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Potassium with Losartan?
NutriStack classifies the Potassium and Losartan pairing as conflict: Losartan blocks angiotensin II type 1 receptors, reducing aldosterone secretion and thereby decreasing renal potassium excretion. Adding potassium supplementation on... Avoid potassium supplementation while taking losartan unless directed by your prescriber with regular lab monitoring. Do not use... Always confirm with your prescriber.
Check your whole stack
See how losartan fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.