Medication·Interactions & depletion·Reviewed June 9, 2026
Losartan/Hydrochlorothiazide interactions.
Losartan/Hydrochlorothiazide has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Potassium, Magnesium, Zinc, and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Losartan/Hydrochlorothiazide at a glance.
A quick, data-grounded summary. The full tables are below.
Losartan/Hydrochlorothiazide has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Potassium, Magnesium, Zinc, and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with losartan/hydrochlorothiazide.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Calcium | Caution | Hydrochlorothiazide decreases urinary calcium excretion; high-dose calcium can contribute to hypercalcemia in susceptible patients. |
| Garlic Extract | Caution | Garlic extract has a modest blood-pressure-lowering effect in hypertensive patients. When added to an effective antihypertensive combination such as... |
| Potassium | Caution | Potassium supplements can cause hyperkalemia from losartan even though hydrochlorothiazide can lower potassium in some patients. |
| Vitamin D3 | Caution | Vitamin D3 increases intestinal calcium absorption. Combined with hydrochlorothiazide's calcium-sparing effect on the kidney, high-dose vitamin D... |
| Magnesium Glycinate | Synergy | Losartan/Hydrochlorothiazide can lower magnesium in some patients, and magnesium replacement may be needed when deficiency is documented. |
What losartan/hydrochlorothiazide can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Potassium | Moderate | Hydrochlorothiazide increases urinary potassium loss, although losartan may offset or reverse this in some patients. | Potassium only if prescribed | Serum potassium |
| Magnesium | Moderate | Thiazide diuretics can increase urinary magnesium loss. | Magnesium Glycinate | Serum magnesium |
| Zinc | Mild | Thiazide diuretics increase urinary zinc excretion through enhanced distal tubular fluid flow and reduced zinc reabsorption, which can lower body... | Zinc gluconate | Plasma zinc |
| Sodium | Mild | As a natriuretic agent, hydrochlorothiazide directly increases renal sodium excretion; combined with reduced thirst or low sodium intake in older... | – | Serum sodium |
The full losartan/hydrochlorothiazide profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common losartan/hydrochlorothiazide questions.
Quick answers drawn from the tables above.
What interacts with Losartan/Hydrochlorothiazide?
In the NutriStack database, Losartan/Hydrochlorothiazide has 5 documented interactions. The most notable include Calcium, Garlic Extract, Potassium, Vitamin D3, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Does Losartan/Hydrochlorothiazide deplete any nutrients?
Losartan/Hydrochlorothiazide is associated with lowering Potassium, Magnesium, Zinc, and Sodium with prolonged use. Useful biomarkers to monitor include Serum potassium, Serum magnesium, and Plasma zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Calcium with Losartan/Hydrochlorothiazide?
NutriStack classifies the Calcium and Losartan/Hydrochlorothiazide pairing as caution: Hydrochlorothiazide decreases urinary calcium excretion; high-dose calcium can contribute to hypercalcemia in susceptible patients. Avoid excessive calcium supplementation and monitor calcium if using high doses or vitamin D, or if kidney disease or hyperparathyroidism is present. Always confirm with your prescriber.
Check your whole stack
See how losartan/hydrochlorothiazide fits your supplements.
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