Medication·Interactions & depletion·Reviewed June 9, 2026
Metoprolol interactions.
Metoprolol has 14 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Metoprolol at a glance.
A quick, data-grounded summary. The full tables are below.
Metoprolol has 14 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with metoprolol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Coenzyme Q10 | Caution | Beta-blockers including metoprolol may reduce endogenous CoQ10 levels by inhibiting CoQ10-dependent mitochondrial enzymes. Some studies suggest... |
| Garlic Extract | Caution | Aged garlic extract lowers systolic blood pressure by roughly 8 mmHg in hypertensive patients, comparable to first-line antihypertensives. Added to... details → |
| L-Arginine | Caution | L-Arginine is a nitric oxide precursor that lowers blood pressure on its own. Stacked with metoprolol's beta1 blockade, the combined fall in blood... details → |
| L-Citrulline | Caution | L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than arginine itself, producing nitric-oxide-mediated... details → |
| L-Theanine | Caution | L-Theanine blunts stress-induced rises in blood pressure and heart rate in high-stress-responder subjects. Combined with metoprolol, the effect is... |
| Potassium | Caution | Metoprolol alone does not significantly affect potassium levels. However, it is frequently prescribed alongside diuretics (e.g., hydrochlorothiazide... details → |
| Taurine | Caution | Taurine modestly lowers both systolic and diastolic blood pressure (~3 mmHg each in meta-analysis) and has direct heart-rate-lowering effects.... details → |
| Acetyl-L-Carnitine | Synergy | Acetyl-L-carnitine supports cardiac mitochondrial function and modestly lowers diastolic blood pressure. Combined with metoprolol in heart failure... |
| Coenzyme Q10 Ubiquinol | Synergy | Beta-blockers including metoprolol inhibit CoQ10-dependent mitochondrial enzymes, reducing endogenous CoQ10 levels. Metoprolol inhibits NADH-oxidase... details → |
| Fish Oil | Synergy | Omega-3 fatty acids in fish oil produce small but consistent reductions in blood pressure (~2-3 mmHg systolic at doses of 2-3 g/day) and lower... details → |
| L-Carnitine | Synergy | L-Carnitine modestly lowers diastolic blood pressure and supports cardiac fatty-acid oxidation. Adjunctive use with metoprolol in heart failure or... details → |
| Magnesium Glycinate | Synergy | Magnesium acts as a natural calcium channel blocker and can enhance the blood pressure-lowering and heart rate-reducing effects of metoprolol... details → |
| Melatonin | Synergy | Metoprolol suppresses endogenous melatonin production by approximately 50% through blockade of beta-1 adrenergic receptors on the pineal gland. This... details → |
| Resveratrol | Synergy | High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol, the net... details → |
What metoprolol can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Coenzyme Q10 | Plasma CoQ10 |
The full metoprolol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common metoprolol questions.
Quick answers drawn from the tables above.
What interacts with Metoprolol?
In the NutriStack database, Metoprolol has 14 documented interactions. The most notable include Coenzyme Q10, Garlic Extract, L-Arginine, L-Citrulline, and L-Theanine. Check any specific combination before taking it and confirm with your prescriber.
Does Metoprolol deplete any nutrients?
Metoprolol is associated with lowering CoQ10 with prolonged use. Useful biomarkers to monitor include Plasma CoQ10. Ask your prescriber before adding any replacement supplement.
Is it safe to take Coenzyme Q10 with Metoprolol?
NutriStack classifies the Coenzyme Q10 and Metoprolol pairing as caution: Beta-blockers including metoprolol may reduce endogenous CoQ10 levels by inhibiting CoQ10-dependent mitochondrial enzymes. Some studies suggest CoQ10 supplementation... Consider CoQ10 supplementation (100-200mg/day) if experiencing fatigue or muscle weakness on metoprolol. CoQ10 does not interfere with metoprolol's... Always confirm with your prescriber.
Check your whole stack
See how metoprolol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.