Medication·Interactions & depletion·Reviewed June 9, 2026
Nebivolol interactions.
Nebivolol has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Nebivolol at a glance.
A quick, data-grounded summary. The full tables are below.
Nebivolol has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Coenzyme Q10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with nebivolol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Berberine may lower glucose, while beta blockers can mask adrenergic warning signs of hypoglycemia such as tachycardia. |
| Coenzyme Q10 | Caution | Beta-blockers, including nebivolol, can inhibit CoQ10-dependent enzymes and may lower endogenous CoQ10 levels (a recognized class effect, best... |
| Garlic Extract | Caution | Garlic extract has a modest antihypertensive effect, particularly aged garlic extract, and may add to the blood-pressure-lowering action of... |
| L-Citrulline | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Nebivolol. |
| Magnesium Glycinate | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Nebivolol. |
| St. John's Wort | Caution | St. John's Wort is a broad inducer of drug-metabolizing enzymes. While nebivolol is primarily a CYP2D6 substrate, St. John's Wort can reduce the... |
What nebivolol can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Coenzyme Q10 | Mild | Beta-adrenergic blockers, including nebivolol, are recognized as a class to lower circulating coenzyme Q10 (ubiquinone). The proposed mechanism is... | Coenzyme Q10 (ubiquinone or ubiquinol) | Plasma/serum coenzyme Q10 concentration (not routinely measured clinically) |
The full nebivolol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common nebivolol questions.
Quick answers drawn from the tables above.
What interacts with Nebivolol?
In the NutriStack database, Nebivolol has 6 documented interactions. The most notable include Berberine, Coenzyme Q10, Garlic Extract, L-Citrulline, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Does Nebivolol deplete any nutrients?
Nebivolol is associated with lowering Coenzyme Q10 with prolonged use. Useful biomarkers to monitor include Plasma/serum coenzyme Q10 concentration (not routinely measured clinically). Ask your prescriber before adding any replacement supplement.
Is it safe to take Berberine with Nebivolol?
NutriStack classifies the Berberine and Nebivolol pairing as caution: Berberine may lower glucose, while beta blockers can mask adrenergic warning signs of hypoglycemia such as tachycardia. Use glucose monitoring if diabetic or taking glucose-lowering drugs; do not rely only on palpitations as a hypoglycemia warning sign. Always confirm with your prescriber.
Check your whole stack
See how nebivolol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.