Medication·Interactions & depletion·Reviewed June 9, 2026
Niacin (Prescription) interactions.
Niacin (Prescription) has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Chromium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Niacin (Prescription) at a glance.
A quick, data-grounded summary. The full tables are below.
Niacin (Prescription) has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower Chromium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with niacin (prescription).
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Berberine | Caution | Berberine may lower glucose, while prescription niacin can worsen glycemic control; combining them can make glucose response less predictable. |
| Green Tea Extract | Caution | Concentrated green tea extract has been associated with liver injury, which can complicate use of hepatotoxic drugs such as Niacin (Prescription). |
| Milk Thistle | Caution | High-dose prescription niacin, especially sustained- or extended-release formulations, can cause dose-dependent hepatotoxicity ranging from... |
| Quercetin | Caution | Prescription niacin causes prostaglandin-mediated cutaneous flushing (warmth, redness, itching), the most common reason for discontinuation.... |
| Vitamin B6 | Caution | Niacin (nicotinic acid) is a B-vitamin (vitamin B3). High-dose prescription niacin overlaps with niacin supplements and is sometimes combined with... |
| Fish Oil | Synergy | Prescription niacin and fish oil (omega-3 fatty acids EPA/DHA) both lower triglycerides through complementary mechanisms and are sometimes used... |
What niacin (prescription) can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Chromium | Mild | High-dose nicotinic acid is a component of glucose tolerance factor and influences chromium handling; pharmacologic niacin therapy has been... | Chromium (chromium picolinate) only if deficiency or niacin-associated glucose intolerance is a concern | No reliable routine clinical assay for chromium status; monitor fasting glucose and HbA1c as functional indicators of glycemic control |
The full niacin (prescription) profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common niacin (prescription) questions.
Quick answers drawn from the tables above.
What interacts with Niacin (Prescription)?
In the NutriStack database, Niacin (Prescription) has 6 documented interactions. The most notable include Berberine, Green Tea Extract, Milk Thistle, Quercetin, and Vitamin B6. Check any specific combination before taking it and confirm with your prescriber.
Does Niacin (Prescription) deplete any nutrients?
Niacin (Prescription) is associated with lowering Chromium with prolonged use. Useful biomarkers to monitor include No reliable routine clinical assay for chromium status; monitor fasting glucose and HbA1c as functional indicators of glycemic control. Ask your prescriber before adding any replacement supplement.
Is it safe to take Berberine with Niacin (Prescription)?
NutriStack classifies the Berberine and Niacin (Prescription) pairing as caution: Berberine may lower glucose, while prescription niacin can worsen glycemic control; combining them can make glucose response less predictable. Monitor fasting glucose or A1c when starting or stopping either agent. Always confirm with your prescriber.
Check your whole stack
See how niacin (prescription) fits your supplements.
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