Medication·Interactions & depletion·Reviewed June 9, 2026
Perindopril interactions.
Perindopril has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Perindopril at a glance.
A quick, data-grounded summary. The full tables are below.
Perindopril has 5 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc and Sodium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with perindopril.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Potassium | Conflict | ACE inhibitors such as perindopril reduce aldosterone secretion, decreasing renal potassium excretion. Adding supplemental potassium can produce... |
| Garlic Extract | Caution | Garlic extract has modest blood-pressure-lowering properties demonstrated in meta-analyses. Combined with perindopril, the antihypertensive effects... |
| Iron | Caution | ACE inhibitors are associated with a dry cough thought to involve bradykinin and substance P accumulation. Small studies suggest oral or intravenous... |
| L-Citrulline | Caution | L-Citrulline may add to the blood-pressure-lowering effect of Perindopril. |
| Magnesium Glycinate | Caution | Magnesium Glycinate may add to the blood-pressure-lowering effect of Perindopril. |
What perindopril can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Mild | ACE inhibitors can increase urinary zinc excretion and chelate zinc, potentially lowering plasma and intracellular zinc concentrations over... | Zinc | Serum or plasma zinc |
| Sodium | Mild | ACE inhibitors reduce angiotensin II and aldosterone, decreasing renal sodium reabsorption and promoting natriuresis, which can lower serum sodium... | – | Serum sodium |
The full perindopril profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common perindopril questions.
Quick answers drawn from the tables above.
What interacts with Perindopril?
In the NutriStack database, Perindopril has 5 documented interactions. The most notable include Potassium, Garlic Extract, Iron, L-Citrulline, and Magnesium Glycinate. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Perindopril?
Perindopril is flagged against 1 substance in the database, including Potassium. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Perindopril deplete any nutrients?
Perindopril is associated with lowering Zinc and Sodium with prolonged use. Useful biomarkers to monitor include Serum or plasma zinc and Serum sodium. Ask your prescriber before adding any replacement supplement.
Is it safe to take Potassium with Perindopril?
NutriStack classifies the Potassium and Perindopril pairing as conflict: ACE inhibitors such as perindopril reduce aldosterone secretion, decreasing renal potassium excretion. Adding supplemental potassium can produce clinically significant... Avoid routine potassium supplementation while taking perindopril unless prescribed and monitored by a clinician. Also avoid potassium-containing... Always confirm with your prescriber.
Check your whole stack
See how perindopril fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.