Medication·Interactions & depletion·Reviewed June 9, 2026
Phenelzine interactions.
Phenelzine has 5 documented interactions in the NutriStack database, including 5 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Vitamin B6. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Phenelzine at a glance.
A quick, data-grounded summary. The full tables are below.
Phenelzine has 5 documented interactions in the NutriStack database, including 5 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Vitamin B6. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with phenelzine.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| 5-HTP | Contraindicated | 5-HTP increases serotonin synthesis while Phenelzine reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and... details → |
| L-Tryptophan | Contraindicated | L-Tryptophan feeds serotonin synthesis while Phenelzine reduces serotonin breakdown, increasing risk of serotonin syndrome. details → |
| St. John's Wort | Contraindicated | St. John's Wort is serotonergic and is inappropriate with irreversible MAOIs. |
| Tyramine / High-Tyramine Foods | Contraindicated | Phenelzine is an irreversible MAOI that can sharply reduce tyramine breakdown. High-tyramine foods can then trigger sudden, severe blood-pressure... details → |
| Rhodiola Rosea | Conflict | Rhodiola may have stimulant and monoaminergic effects, which are risky during nonselective MAO inhibition. |
What phenelzine can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Vitamin B6 | Moderate | Phenelzine is a hydrazine derivative that can bind or inactivate pyridoxal-5-phosphate, reducing active vitamin B6 availability and impairing... | Vitamin B6 | Plasma pyridoxal-5-phosphate and clinical monitoring for paresthesias or neuropathy |
The full phenelzine profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common phenelzine questions.
Quick answers drawn from the tables above.
What interacts with Phenelzine?
In the NutriStack database, Phenelzine has 5 documented interactions. The most notable include 5-HTP, L-Tryptophan, St. John's Wort, Tyramine / High-Tyramine Foods, and Rhodiola Rosea. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Phenelzine?
Phenelzine is flagged against 5 substances in the database, including 5-HTP, L-Tryptophan, St. John's Wort, Tyramine / High-Tyramine Foods, and Rhodiola Rosea. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Phenelzine deplete any nutrients?
Phenelzine is associated with lowering Vitamin B6 with prolonged use. Useful biomarkers to monitor include Plasma pyridoxal-5-phosphate and clinical monitoring for paresthesias or neuropathy. Ask your prescriber before adding any replacement supplement.
Is it safe to take 5-HTP with Phenelzine?
NutriStack classifies the 5-HTP and Phenelzine pairing as contraindicated: 5-HTP increases serotonin synthesis while Phenelzine reduces monoamine breakdown. Combining them can cause dangerous serotonergic excess and serotonin syndrome. Do NOT combine 5-HTP with Phenelzine. Use only if the prescriber managing Phenelzine explicitly directs it and provides washout instructions. Always confirm with your prescriber.
Check your whole stack
See how phenelzine fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.