Medication·Interactions & depletion·Reviewed June 9, 2026
Pravastatin interactions.
Pravastatin has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Pravastatin at a glance.
A quick, data-grounded summary. The full tables are below.
Pravastatin has 4 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with pravastatin.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Quercetin | Caution | Quercetin increased pravastatin exposure in a human study by inhibiting OATP1B1-mediated transport. The average increase was modest, but it could... details → |
| Vitamin B3 | Caution | High-dose Vitamin B3 as niacin can increase adverse effects when added to statin therapy, even though pravastatin has fewer CYP3A4 interaction... details → |
| Coenzyme Q10 | Synergy | All statins reduce CoQ10 levels by inhibiting the mevalonate pathway. Pravastatin has lower myopathy risk but still depletes CoQ10. Supplementation... details → |
| Coenzyme Q10 Ubiquinol | Synergy | Pravastatin is less lipophilic than several other statins but still inhibits the mevalonate pathway that supplies CoQ10 precursors. Ubiquinol may... details → |
What pravastatin can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Moderate | HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis. | Coenzyme Q10 Ubiquinol | Plasma CoQ10 |
The full pravastatin profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common pravastatin questions.
Quick answers drawn from the tables above.
What interacts with Pravastatin?
In the NutriStack database, Pravastatin has 4 documented interactions. The most notable include Quercetin, Vitamin B3, Coenzyme Q10, and Coenzyme Q10 Ubiquinol. Check any specific combination before taking it and confirm with your prescriber.
Does Pravastatin deplete any nutrients?
Pravastatin is associated with lowering CoQ10 with prolonged use. Useful biomarkers to monitor include Plasma CoQ10. Ask your prescriber before adding any replacement supplement.
Is it safe to take Quercetin with Pravastatin?
NutriStack classifies the Quercetin and Pravastatin pairing as caution: Quercetin increased pravastatin exposure in a human study by inhibiting OATP1B1-mediated transport. The average increase was modest, but it could matter in people with... Use high-dose quercetin cautiously with pravastatin, especially if you have kidney disease, a history of statin muscle symptoms, or other... Always confirm with your prescriber.
Check your whole stack
See how pravastatin fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.