Medication·Interactions & depletion·Reviewed June 9, 2026
Propranolol interactions.
Propranolol has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Propranolol at a glance.
A quick, data-grounded summary. The full tables are below.
Propranolol has 6 documented interactions in the NutriStack database. Prolonged use is also associated with lower CoQ10. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with propranolol.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Ashwagandha | Caution | Ashwagandha lowers cortisol and dampens sympathetic activity, which can modestly reduce heart rate and blood pressure. Combined with propranolol,... |
| Garlic Extract | Caution | Garlic extract lowers blood pressure on its own and, in animal studies, has been shown to potentiate the antihypertensive and cardioprotective... details → |
| Green Tea Extract | Caution | Green tea extract contains caffeine, which propranolol blunts the cardiovascular response to, and vice versa. High-dose green tea extract can also... |
| Coenzyme Q10 | Synergy | Propranolol is the strongest CoQ10-enzyme inhibitor among beta-blockers, which contributes to fatigue and exercise intolerance. CoQ10... details → |
| L-Theanine | Synergy | Both L-theanine and propranolol blunt the cardiovascular response to acute stress. The combination can produce slightly greater anxiolytic effects,... |
| Melatonin | Synergy | Propranolol suppresses nocturnal melatonin synthesis by blocking pineal beta-1 receptors. Melatonin supplementation can restore sleep quality in... details → |
What propranolol can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| CoQ10 | Mild | Chronic beta-blocker therapy has been associated with lower tissue CoQ10 status and reduced mitochondrial electron transport support. | Coenzyme Q10 | Plasma CoQ10 |
The full propranolol profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common propranolol questions.
Quick answers drawn from the tables above.
What interacts with Propranolol?
In the NutriStack database, Propranolol has 6 documented interactions. The most notable include Ashwagandha, Garlic Extract, Green Tea Extract, Coenzyme Q10, and L-Theanine. Check any specific combination before taking it and confirm with your prescriber.
Does Propranolol deplete any nutrients?
Propranolol is associated with lowering CoQ10 with prolonged use. Useful biomarkers to monitor include Plasma CoQ10. Ask your prescriber before adding any replacement supplement.
Is it safe to take Ashwagandha with Propranolol?
NutriStack classifies the Ashwagandha and Propranolol pairing as caution: Ashwagandha lowers cortisol and dampens sympathetic activity, which can modestly reduce heart rate and blood pressure. Combined with propranolol, the effect can be... Ashwagandha 300-600 mg/day is generally compatible with propranolol but check resting heart rate and blood pressure when starting. Reduce the dose... Always confirm with your prescriber.
Check your whole stack
See how propranolol fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.