Medication·Interactions & depletion·Reviewed June 9, 2026
Rabeprazole interactions.
Rabeprazole has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Vitamin B12, Iron, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Rabeprazole at a glance.
A quick, data-grounded summary. The full tables are below.
Rabeprazole has 5 documented interactions in the NutriStack database. Prolonged use is also associated with lower Magnesium, Vitamin B12, Iron, and Calcium. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with rabeprazole.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Iron | Caution | Rabeprazole can reduce non-heme iron absorption, making oral iron response less reliable. |
| Vitamin B12 | Caution | Rabeprazole can reduce absorption of food-bound vitamin B12 during prolonged therapy. |
| Calcium | Timing Sensitive | Acid suppression may reduce absorption of calcium carbonate more than calcium citrate and long-term PPI therapy is associated with fracture risk. |
| Magnesium Glycinate | Synergy | Magnesium supplementation may help correct low magnesium during PPI therapy, but severe PPI-associated hypomagnesemia can require stopping the PPI. |
| Vitamin C | Synergy | Vitamin C can improve non-heme iron absorption and may partly offset reduced iron solubility during acid suppression. |
What rabeprazole can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Magnesium | Significant | Long-term PPI therapy can impair intestinal magnesium absorption and cause clinically significant hypomagnesemia. | Magnesium Glycinate | Serum magnesium |
| Vitamin B12 | Moderate | Reduced gastric acid can impair release of protein-bound vitamin B12 from food. | Vitamin B12 | Serum vitamin B12 with methylmalonic acid when needed |
| Iron | Moderate | Reduced gastric acidity can lower solubilization and absorption of non-heme iron. | Iron | Ferritin, transferrin saturation, hemoglobin |
| Calcium | Mild | Acid suppression may reduce absorption of some calcium salts and is associated with fracture risk during high-dose or long-term therapy. | Calcium | 25-hydroxyvitamin D, calcium intake assessment, bone density when indicated |
The full rabeprazole profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common rabeprazole questions.
Quick answers drawn from the tables above.
What interacts with Rabeprazole?
In the NutriStack database, Rabeprazole has 5 documented interactions. The most notable include Iron, Vitamin B12, Calcium, Magnesium Glycinate, and Vitamin C. Check any specific combination before taking it and confirm with your prescriber.
Does Rabeprazole deplete any nutrients?
Rabeprazole is associated with lowering Magnesium, Vitamin B12, Iron, and Calcium with prolonged use. Useful biomarkers to monitor include Serum magnesium, Serum vitamin B12 with methylmalonic acid when needed, and Ferritin, transferrin saturation, hemoglobin. Ask your prescriber before adding any replacement supplement.
Is it safe to take Iron with Rabeprazole?
NutriStack classifies the Iron and Rabeprazole pairing as caution: Rabeprazole can reduce non-heme iron absorption, making oral iron response less reliable. Monitor ferritin and hemoglobin if iron is prescribed; consider timing, vitamin C coadministration, or alternative iron strategies when response is... Always confirm with your prescriber.
Check your whole stack
See how rabeprazole fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.