Medication·Interactions & depletion·Reviewed June 9, 2026
Ramipril interactions.
Ramipril has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Ramipril at a glance.
A quick, data-grounded summary. The full tables are below.
Ramipril has 6 documented interactions in the NutriStack database, including 1 flagged to avoid or as a serious conflict. Prolonged use is also associated with lower Zinc. The full interaction list, depletion table, and replacement suggestions are below. None of this is a substitute for your prescriber's advice.
Substances that interact with ramipril.
Every supplement and medication in the NutriStack database with a documented interaction with this drug, highest-severity first. Open any pair for the mechanism and sources.
| Substance | Interaction | What happens |
|---|---|---|
| Potassium | Conflict | Ramipril reduces aldosterone secretion, creating significant hyperkalemia risk with potassium supplements. |
| Lithium Orotate | Caution | Ramipril reduces sodium reabsorption and lowers glomerular filtration, which causes the kidney to retain lithium. Case reports with ACE inhibitors... details → |
| Coenzyme Q10 | Synergy | Coenzyme Q10 lowers blood pressure modestly through improved endothelial function and reduced oxidative stress. A meta-analysis of 12 clinical... details → |
| Fish Oil | Synergy | Fish Oil reduces blood pressure modestly (about 3/1.5 mm Hg in hypertensives) and has independent renoprotective effects through suppression of ACE... details → |
| Garlic Extract | Synergy | Garlic Extract lowers blood pressure modestly and has independent ACE-inhibitory activity in vitro. When combined with ramipril the effects are... details → |
| Pine Bark Extract | Synergy | Pine Bark Extract (Pycnogenol) lowers blood pressure (about 3 mm Hg systolic and 3 mm Hg diastolic in a meta-analysis) and has independent... details → |
What ramipril can deplete.
Nutrients this medication is associated with lowering over time, with the mechanism, a suggested replacement where one applies, and the biomarker to monitor. Discuss any replacement with your prescriber first.
| Nutrient | Severity | How it happens | Replace with | Monitor |
|---|---|---|---|---|
| Zinc | Mild | ACE inhibition has been associated with increased urinary zinc excretion and altered taste in some long-term users. | Zinc Picolinate | Serum zinc |
The full ramipril profile.
Uses, typical dosing, side effects, and the cited evidence for this medication.
Common ramipril questions.
Quick answers drawn from the tables above.
What interacts with Ramipril?
In the NutriStack database, Ramipril has 6 documented interactions. The most notable include Potassium, Lithium Orotate, Coenzyme Q10, Fish Oil, and Garlic Extract. Check any specific combination before taking it and confirm with your prescriber.
Which substances should I avoid with Ramipril?
Ramipril is flagged against 1 substance in the database, including Potassium. These pairings carry a higher risk and should be reviewed with a clinician before combining.
Does Ramipril deplete any nutrients?
Ramipril is associated with lowering Zinc with prolonged use. Useful biomarkers to monitor include Serum zinc. Ask your prescriber before adding any replacement supplement.
Is it safe to take Potassium with Ramipril?
NutriStack classifies the Potassium and Ramipril pairing as conflict: Ramipril reduces aldosterone secretion, creating significant hyperkalemia risk with potassium supplements. Avoid potassium supplements unless prescribed. Monitor serum K+ regularly. Always confirm with your prescriber.
Check your whole stack
See how ramipril fits your supplements.
NutriStack screens your full routine for interactions and depletions, and updates the moment you change it.